Oxaliplatin

Product Name: Oxaliplatin
CAS No.: 61825-94-3
MF: C8H12N2O4Pt
MW: 395.28
Melting point: >300 °C (lit.)
Storage temp.: Sealed in dry,2-8°C
Solubility: Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol.
Form: powder
Color: White to off-white
Standard: USP/EP/BP

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Description

Oxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death. Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively. Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.